Endocrine Abstracts

The need for insulin delivery not based on syringe and needle derives from problems associated with control of diabetes by this method. These include dislike of injections producing poor compliance; adverse insulin pharmacokinetics (basal insulin not constant, sc absorption of short-acting insulin too slow, highly variable absorption); hyperinsulinaemia due to peripheral rather than portal administration; and lack of feedback control due to absence of continuous glucose sensin...